A2O

A vertically integrated cannabis operator, focused in developing precision formulation products tailored for personalized medical needs

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Cannabis Medical
Applications

* Conditions and pathologies where medicinal cannabis products have approved by INFARMED.

Gilles de la Tourette syndrome*

THC-containing products are effective and safe in the treatment of tics and comorbidities.

THC-rich preparations, report higher therapeutic value with lower incidence of adverse side-effects.

Currently there are few cannabis-based medicines in development specifically for Tourette Syndrome.

Spasticity associated to Multiple Sclerosis (MS) and Spinal Cord lesions*

Cannabis-derived compounds can reduce severe spasticity associated with MS and autoimmune inflammation.

THC is effective in reducing tremor and ataxia.

CBD is effective in reducing dystonia.

Intractable-and Chemotherapy-Induced Nausea and Vomiting*

Cannabinoids are effective in preventing weight loss and successfully used to increase food motivation.

Cannabinoids reduce the energy consumption required to produce body heat and power muscle cells.

For high antiemetic capacity with low side effects, the optimal dose of plant-derived THC formulations is estimated to be ~7mg/m2.

Chronic Pain*

THC-containing products reduce pain perception and increase tolerance to pain.

Inhaled medical cannabis reduces opiate consumption and acts synergistically with opiates to reduce chronic pain.

Oral and oromucosal methods of administration have been shown to cause more adverse side -effects than inhaled medical cannabis products for the treatment of chronic pain.

Stimulating appetite in HIV and Cancer patients undergoing palliative care*

THC has equalled or higher antiemetic capacity than other currently available pharmaceuticals.

Plant-derived THC-containing products have higher antiemetic capacity than synthetic cannabinoids

Clinical data demonstrate that cannabinoids have anti-inflammatory effects in patients with HIV.

Severe treatment-resistant epilepsy including Dravet and Lennox-Gastaut syndrome patients*

CBD is highly effective for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.

CBD is the most effective treatment for childhood drug-resistant epilepsy, with no reported adverse side effects.

Studies in children have demonstrated that cannabis derived compounds are well tolerated with low incidence of adverse side effects.

Treatment-resistant Glaucoma*

Oral administration of THC has been demonstrated to temporarily reduce intra-ocular pressure by 30%.

Not recommended by the Israeli and American Glaucoma Societies, due to temporary effects, development of resistance and acquired side effects.

Cancer

Preclinical studies demonstrate that cannabinoids have a protective effect over certain cancer types.

Cannabinoids can modulate the proliferation, death and angiogenesis of different cancer cells, without affecting the health of normal cells.

Cannabis-based therapies may prevent or reduce the development and progression of different cancer types (including lung cancer, gliomas, glioblastoma multiforme, skin cancer, lymphomas, breast cancer, prostate cancer, uterine cancer, neuroblastoma, and thyroid epithelioma).

Anxiety, Depression and PTSD

Cannabinoids may exert anti-anxiety effects at low doses.

THC-based products provide positive psychological effects including sleep enhancement, as well as, reduction in anxiety and depression.

Sleeping disorders

Orally administered THC increases deep sleep duration but decreases REM sleep duration.

Prolonged treatment with high doses of THC increases REM sleep although some patients report a “morning hangover” effect.

CBD has been demonstrated to also increase sleep quality without the intoxicating side effects of THC.

* Conditions and pathologies where medicinal cannabis products have approved by INFARMED.

We believe that everyone has something different to offer and that efficient problem-solving capacity is only achieved with the combined critical thinking of a motivated team.